It's not a question of the number of previous entries, but in the visa regime. Despite the fact that most of the visas are now Schengen, that is, they apply to all countries of the Schengen agreement, it matters, through which consulate they were opened.

It is advisable to make the first visa flight to the country that opened the visa. If you have a Spanish visa open, then it is necessary to go to Spain in the first trip, this is the most correct. Other countries do not need to visit, and no one at the border will deploy.

Then you can use the visa as you wish within the terms of its validity.