Like most diplomatic missions of foreign states in Moscow, the Portuguese Embassy is located in the Central Administrative District. It occupies a two-story building at number 1 in the Botanical Lane of the Meshchansky District.

Its name is due to the proximity to the botanical garden of Moscow University, now known as the "Pharmacy garden."

The house stands at the corner of two alleys, so sometimes, instead of the official address (Botanicheskiy, 1), in some sources another is indicated, per. Grocholsky, 3. This is not entirely accurate, although you can find an embassy on this information.

The closest metro stations to it are "Prospekt Mira", "Sukharevskaya".